NMN vs NR: Kľúčové rozdiely
Úplne nová autoritatívna štúdia je tu! Experiment z roku 2025 od tímu Northwest A&F University, publikovaný v Journal of Microbiology (Core Journal, DOI: 10.13343/j.cnki.wsxb.20250174), odhalil s rigoróznymi dáta the true health effects of NMN and NR—two NAD+ precursors that both support gut health, fight inflammation and oxidation, yet each has its own distinct strengths. After reading this, you’ll never have to struggle over which to choose again!
ČASŤ 01
The Common Power: NMN and NR Both Build the Body’s Foundation
The study divided 45 C57 mice into three groups: one control group drinking plain water, and two groups gavaged with NMN or NR (400 mg/(kg·d), 5 times per week). After 8 weeks, the results were astonishing: both compounds achieved consensus in regulating gut health and metabolism.
Prebudovanie črevnej mikrobioty: viac prospešných baktérií, viac stability
The gut microbiota functions like a “miniature ecosystem”—the richer and more balanced it is, the healthier the host. The experiment found that after NMN or NR supplementation, the “richness” (Chao1 index) and “diversity” (Shannon index) of gut microbiota in mice increased significantly, meaning more beneficial bacteria and fewer harmful ones.
Obrázok 1: Účinky kŕmenia NMN a NR na diverzitu črevných mikróbov u myší.
A: Comparison of intestinal microbial α-diversity between the control and NMN groups;
B: Comparison of intestinal microbial α-diversity between the control and NR groups.
The dominant bacterial phyla also shifted: Bacteroidota (responsible for nutrient absorption and immune regulation) and Pseudomonadota increased, while Actinomycetota (associated with inflammation when imbalanced) decreased, without causing dysbiosis—essentially adding a “stabilizer” to the gut.
Obrázok 2: Účinky kŕmenia NMN a NR na diverzitu črevných mikróbov u myší.
C: Druhová abundancia na úrovni kmeňov v skupine kŕmenej NMN;
D: Druhová abundancia na úrovni kmeňov v skupine kŕmenej NR
Protizápalový a antioxidačný dvojitý posilňovač: ochrana zdravia od metabolizmu po gény
Zápal a oxidačné poškodenie sú koreňovými príčinami mnohých porúch. NMN a NR im čelia z oboch strán:
Metabolically: both significantly upregulated anti-inflammatory fatty acid metabolites such as oleic acid and linoleic acid, as well as antioxidant metabolites like salicylic acid—adding a “natural defense shield” to the body.
Obrázok 3: Heat mapa diferenciálnych metabolitov v skupine kŕmenej NMN
Obrázok 4: Heat mapa diferenciálnych metabolitov v skupine kŕmenej NR
Genetically: quantitative PCR testing confirmed that both compounds inhibited the expression of pro-inflammatory factors such as TNF-α and IL-6, effectively reducing inflammation at its source.
Obrázok 5: Účinky kŕmenia NMN a NR na črevné zápalové faktory u myší.
A: PCR expression of tumor necrosis factor-α (TNF-α);
B: PCR expresia interleukínu 6 (IL-6);
ČASŤ 02
Kľúčové rozdiely: Výber NMN alebo NR pre presnú optimalizáciu zdravia
While they share core benefits, the study clearly identified each compound’s area of expertise. Choose according to your needs for double the results.
NMN: The “Guardian” of Gut Barrier Health
If you often experience gut discomfort or worry about mucosal damage, NMN is the better choice. It significantly increases the number of goblet cells in the colon—these “mucus factories” secrete protective mucus that forms a physical barrier between harmful bacteria and intestinal epithelium, enhancing gut resistance. NMN also more strongly modulates gut microbiota diversity and strengthens local immunity through the “Bacteroidota–fatty acid” axis—essentially a personalized gut health solution.
Obrázok 6: Štatistika pohárikovitých buniek v hrubom čreve myší
Figure 7: Comparison of intestinal microbial α-diversity among mice in the control, NMN, and NR groups
NR: The “Booster” for Muscle Vitality
Want to improve muscle strength and reduce fatigue? NR shines here! Surprisingly, mice in the NR group showed significantly higher grip strength than those in the NMN and control groups. Mechanistically, NR upregulates metabolites like arachidic acid (for membrane repair) and L-asparagine (for energy optimization), activates core energy pathways such as the TCA cycle, and downregulates oxidative stress markers like hydroquinone—essentially “energizing and unburdening” muscles for peak performance.
Figure 8: Statistics of mice’s grasping ability
ČASŤ 03
Choose According to Your Needs—Science Over Guesswork
Zistenia z roku 2025 sú jasné: NMN a NR nie sú náhrady, ale doplnkové možnosti. Či už je vaším cieľom ochrana zdravia čriev alebo zvýšenie fyzickej vitality, výber správneho prekurzora NAD+ podporený autoritatívnou literatúrou poskytne vášmu zdraviu dvojitú vrstvu istoty.
ČASŤ 04
Bontac Bio’s NR Malate: Excellence in NR Technology and Quality
Od roku 2012 je Bontac Bio high-tech podnik špecializujúci sa na biokatalytické technológie. Pri vývoji a výrobe NR Malátu (NRHM) spoločnosť integruje svoje jedinečné odborné znalosti a inovácie, čím preukazuje vynikajúce technické a produktové výhody.
Exclusive Technological Edge: Bontac Bio’s NR Malate holds the world’s first crystal form patent, achieving a molecular-level breakthrough that optimizes product performance. As a pioneer in the NMN industry, Bontac applies its globally original all-enzyme catalytic process—an innovation leading the industry. To date, the company has filed over 200 domestic and international invention patents and established China’s first provincial Coenzyme Engineering Technology Research Center, building strong competitive advantages through solid R&D strength.
Uncompromising Product Quality: Bontac enforces rigorous quality control standards. Third-party testing by CTI confirmed that NR Malate contains no detectable cadmium, mercury, lead, or arsenic—ensuring safety from the source. High-performance liquid chromatography revealed almost no impurity peaks, while moisture and microbial indicators far exceeded industry standards, reflecting exceptional purity. Critically, stability testing showed that under normal light-protected conditions, Bontac NR Malate degraded at only half the rate of regular NR (NRCL), ensuring reliable quality in both long-term storage and product applications.
Súlad a certifikácia: Spoločnosť Bontac vlastní medzinárodné certifikáty FSSC 22000, Self-GRAS, FDA, Kosher a HALAL, čo zaručuje plný súlad s globálnymi normami od výskumu a vývoja až po výrobu. Ďalšie štúdie vrátane testov proti fotostarnutiu a testov hladiny NAD+ na zebričkách ďalej potvrdili jej účinnosť a potenciál.
Today, Bontac NR Malate is steadily advancing in compliant applications. For more insights into NR technology or premium product development, follow Bontac Bio—an industry leader in coenzyme biotechnology dedicated to sharing its R&D stories and quality standards.
ČASŤ 01
The Common Power: NMN and NR Both Build the Body’s Foundation
The study divided 45 C57 mice into three groups: one control group drinking plain water, and two groups gavaged with NMN or NR (400 mg/(kg·d), 5 times per week). After 8 weeks, the results were astonishing: both compounds achieved consensus in regulating gut health and metabolism.
Prebudovanie črevnej mikrobioty: viac prospešných baktérií, viac stability
The gut microbiota functions like a “miniature ecosystem”—the richer and more balanced it is, the healthier the host. The experiment found that after NMN or NR supplementation, the “richness” (Chao1 index) and “diversity” (Shannon index) of gut microbiota in mice increased significantly, meaning more beneficial bacteria and fewer harmful ones.
Obrázok 1: Účinky kŕmenia NMN a NR na diverzitu črevných mikróbov u myší.
A: Comparison of intestinal microbial α-diversity between the control and NMN groups;
B: Comparison of intestinal microbial α-diversity between the control and NR groups.
The dominant bacterial phyla also shifted: Bacteroidota (responsible for nutrient absorption and immune regulation) and Pseudomonadota increased, while Actinomycetota (associated with inflammation when imbalanced) decreased, without causing dysbiosis—essentially adding a “stabilizer” to the gut.
Obrázok 2: Účinky kŕmenia NMN a NR na diverzitu črevných mikróbov u myší.
C: Druhová abundancia na úrovni kmeňov v skupine kŕmenej NMN;
D: Druhová abundancia na úrovni kmeňov v skupine kŕmenej NR
Protizápalový a antioxidačný dvojitý posilňovač: ochrana zdravia od metabolizmu po gény
Zápal a oxidačné poškodenie sú koreňovými príčinami mnohých porúch. NMN a NR im čelia z oboch strán:
Metabolically: both significantly upregulated anti-inflammatory fatty acid metabolites such as oleic acid and linoleic acid, as well as antioxidant metabolites like salicylic acid—adding a “natural defense shield” to the body.
Obrázok 3: Heat mapa diferenciálnych metabolitov v skupine kŕmenej NMN
Obrázok 4: Heat mapa diferenciálnych metabolitov v skupine kŕmenej NR
Genetically: quantitative PCR testing confirmed that both compounds inhibited the expression of pro-inflammatory factors such as TNF-α and IL-6, effectively reducing inflammation at its source.
Obrázok 5: Účinky kŕmenia NMN a NR na črevné zápalové faktory u myší.
A: PCR expression of tumor necrosis factor-α (TNF-α);
B: PCR expresia interleukínu 6 (IL-6);
ČASŤ 02
Kľúčové rozdiely: Výber NMN alebo NR pre presnú optimalizáciu zdravia
While they share core benefits, the study clearly identified each compound’s area of expertise. Choose according to your needs for double the results.
NMN: The “Guardian” of Gut Barrier Health
If you often experience gut discomfort or worry about mucosal damage, NMN is the better choice. It significantly increases the number of goblet cells in the colon—these “mucus factories” secrete protective mucus that forms a physical barrier between harmful bacteria and intestinal epithelium, enhancing gut resistance. NMN also more strongly modulates gut microbiota diversity and strengthens local immunity through the “Bacteroidota–fatty acid” axis—essentially a personalized gut health solution.
Obrázok 6: Štatistika pohárikovitých buniek v hrubom čreve myší
Figure 7: Comparison of intestinal microbial α-diversity among mice in the control, NMN, and NR groups
NR: The “Booster” for Muscle Vitality
Want to improve muscle strength and reduce fatigue? NR shines here! Surprisingly, mice in the NR group showed significantly higher grip strength than those in the NMN and control groups. Mechanistically, NR upregulates metabolites like arachidic acid (for membrane repair) and L-asparagine (for energy optimization), activates core energy pathways such as the TCA cycle, and downregulates oxidative stress markers like hydroquinone—essentially “energizing and unburdening” muscles for peak performance.
Figure 8: Statistics of mice’s grasping ability
ČASŤ 03
Choose According to Your Needs—Science Over Guesswork
Zistenia z roku 2025 sú jasné: NMN a NR nie sú náhrady, ale doplnkové možnosti. Či už je vaším cieľom ochrana zdravia čriev alebo zvýšenie fyzickej vitality, výber správneho prekurzora NAD+ podporený autoritatívnou literatúrou poskytne vášmu zdraviu dvojitú vrstvu istoty.
ČASŤ 04
Bontac Bio’s NR Malate: Excellence in NR Technology and Quality
Od roku 2012 je Bontac Bio high-tech podnik špecializujúci sa na biokatalytické technológie. Pri vývoji a výrobe NR Malátu (NRHM) spoločnosť integruje svoje jedinečné odborné znalosti a inovácie, čím preukazuje vynikajúce technické a produktové výhody.
Exclusive Technological Edge: Bontac Bio’s NR Malate holds the world’s first crystal form patent, achieving a molecular-level breakthrough that optimizes product performance. As a pioneer in the NMN industry, Bontac applies its globally original all-enzyme catalytic process—an innovation leading the industry. To date, the company has filed over 200 domestic and international invention patents and established China’s first provincial Coenzyme Engineering Technology Research Center, building strong competitive advantages through solid R&D strength.
Uncompromising Product Quality: Bontac enforces rigorous quality control standards. Third-party testing by CTI confirmed that NR Malate contains no detectable cadmium, mercury, lead, or arsenic—ensuring safety from the source. High-performance liquid chromatography revealed almost no impurity peaks, while moisture and microbial indicators far exceeded industry standards, reflecting exceptional purity. Critically, stability testing showed that under normal light-protected conditions, Bontac NR Malate degraded at only half the rate of regular NR (NRCL), ensuring reliable quality in both long-term storage and product applications.
Súlad a certifikácia: Spoločnosť Bontac vlastní medzinárodné certifikáty FSSC 22000, Self-GRAS, FDA, Kosher a HALAL, čo zaručuje plný súlad s globálnymi normami od výskumu a vývoja až po výrobu. Ďalšie štúdie vrátane testov proti fotostarnutiu a testov hladiny NAD+ na zebričkách ďalej potvrdili jej účinnosť a potenciál.
Today, Bontac NR Malate is steadily advancing in compliant applications. For more insights into NR technology or premium product development, follow Bontac Bio—an industry leader in coenzyme biotechnology dedicated to sharing its R&D stories and quality standards.
