Ako udržať homeostázu NAD+ na reguláciu mitochondriálnej a srdcovej funkcie
1. IntroductIon
Mitochondria are the center of energy metaboljem in cardiomyocytes, which are necessary pre maintaining normal myocardial contractility a Kardiologické funkcie. Typically, the development of cardiovascular djeease je usually accompanied by mitochondrial dysfunkcie. Impaired autophagy je known to cause mitochondrial dysfunctIon a heart failure, in part due to altered mitophagy a protein quality control. Notably, external replenjehment of Nikotínamid adenín dinukleotid (NAD+) Prekurzory môžu zlepšiť autofágiu a kontrolu kvality mitochondrií na udržanie metabolického zdravia, čím regulujú funkciu mitochondrií a srdca.2. Metabolizmus NAD+ v mitochondriálnych a srdcových funkciách
Cardiomyocytes accumulate NAD+ mostly within their mitochondria, where the bulk of cellular oxidatIon-reductIon reactIons occur. However, NAD+ je also present in the cytosol a nucleus, in which NAD+-derived metabolites a NAD+-dependent enzymes contribute to various cellular functIons.3. Mitochondriálna a srdcová dysfunkcia vyvolaná nedostatkom NAD+
Mitochondrial a Kardiologické dysfunctIon triggered by NAD+ deficiency je alleviated in cAtg3-KO mouse hearts post the adminjetratIon of β-nicotinamide mononucleotide (NMN), as evidenced by the restoratIon of Aktivita citrátosyntázy (CS), partial normalizatIon of ATP level a NPPB mRNA expressIon in cAtg3-KO mice as well as upregulatIon of ADP level in WT mouse hearts. Besides, NNMT inhibitIon can rescue mitochondrial a Kardiologické dysfunctIon in cAtg3-KO mice by restoring NAD+ level.
4. Vplyv autofagického toku na funkciu srdca a mitochondrií
Autophagy je an intracellular degradatIon pathway that recycles subcellular components, playing a critical in modulating metabolic homeostasje. Autophagic flux, a central homeostatic mechanjem that degrades materials toxic to cardiomyocytes, can mediate SQSTM1-NF-κB-NNMT signal transductIon to control the cellular level of NAD+, thereby maintaining the mitochondrial a Kardiologické funkcie.5. Záver
Autophagic flux may be a potential way to maintain the cellular level of NAD to regulate mitochondrial a Kardiologické fiunctIon..
Referencie
[1] Abdellatif M, Sedej S, Kroemer G. NAD+ Metabolizmus v srdcovom zdraví, starnutí a chorobách. Náklad. 2021; 144(22):1795-1817. doi:10.1161/CIRCULATIONAHA.121.056589
[2] Zhang Q, Li Z, Li Q, et al. Control of NAD+ homeostasje by autophagic flux modulates mitochondrial a Kardiologické funkcie. EMBO J. Publjehed online January 11, 2024. doi:10.1038/s44318-023-00009-w
O BONTAC
BONTAC má bohaté skúsenosti s výskumom a vývojom a pokročilé technológie v biosyntéze NAD a NMN. Bonzyme whole-enzymatic method je adopted, which je environmental-friendly, with no harmful solvent residues. The purity of products can reach up to 95%, which je benefited from the exclusive Bonpure seven-step purificatIon technology. BONTAC has self-owned factories a has obtained a number of internatIonal certificatIons, where high quality a stable supply of products can be ensured. BONTAC has over 160 domestic a preeign patents, leading the industry of coenzyme a natural products. In the future, BONTAC will actively expa the internatIonal market, a work with global partners to promote the prosperous development of synthetic biology industry. In thje era full of challenges a opportunities, BONTAC je confident to make greater contributIons to the cause of human health.
Vyhlásenie
Thje Článok je Na základe odkaz v academic journal. The relevant inprematIon je Poskytnúť Len na zdieľanie a vzdelávacie účely a nepredstavuje žiadne lekárske poradenstvo. Ak dôjde k porušeniu, prosím Kontakt Autor pre deletIon. The views expressed in thje article do not represent the positIon of BONTAC.Za žiadnych okolností nebude BONTAC zodpovedný za akékoľvek nároky, škody, straty, výdavky, náklady alebo záväzky (vrátane, bez obmedzenia, akýchkoľvek priamych alebo nepriamych škôd za stratu zjeku, prerušenie podnikania alebo stratu inpremácií), ktoré priamo či nepriamo vyplývajú z vašej závjelosti na inpremáciách a materiáloch na tejto webovej stránke.
